HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
نویسندگان
چکیده
منابع مشابه
A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation
DNA topoisomerase IIα (Topo IIα) is the target of an important class of anticancer drugs, but tumor cells can become resistant by reducing the association of the enzyme with chromosomes. Here we describe a critical mechanism of chromatin recruitment and exchange that relies on a novel chromatin tether (ChT) domain and mediates interaction with histone H3 and DNA. We show that the ChT domain con...
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Cell division requires replication of DNA followed by physical segregation of chromosomes and replicated chromatids. DNA replication is likely to leave duplicate sister chromatids wrapped around one another (catenated) at least once every few kilobases (Chapter 15). Then, as the cell enters mitosis, chromosomes are folded (“condensed”) into neatly compacted and segregated mitotic chromosomes ea...
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Recent studies have revealed the importance of Ki-67 and the chromosome periphery in chromosome structure and segregation, but little is known about this elusive chromosome compartment. Here we used correlative light and serial block-face scanning electron microscopy, which we term 3D-CLEM, to model the entire mitotic chromosome complement at ultra-structural resolution. Prophase chromosomes ex...
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ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.63972